SuCComBase

SCC Gene Description

Gene name	MAM1
AGI ID	AT5G23010
Gene length	506
Uniprot ID	Q9FG67
Protein Name	Methylthioalkylmalate synthase 1 chloroplastic
Synonym	IMS3
EC number	EC 2.3.3.-
Entrez Gene	832365
Refseq mrna	NM_122207
Refseq protein	NP_197692
Function	MAM1 catalyses the condensation step of the first three elongation cycles while MAM3 catalyzes the condensation step of all six elongation cycles in met derived GSL biosynthesis (Redovnikovic et al. 2012)
Group	GSL side chain elongation
Reference	Textor et al. (2007); Zang et al. (2009); Redovnikovic et al. (2012); Field et al. (2004); de Kraker et al. (2011); Kroymann et al. (2001)

Organism	AGI ID	Gene Name	Protein Name	Identity	E-Value	Description
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	81	0.00E+00
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	80	0.00E+00
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	80	0.00E+00
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	73	0.00E+00
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	77	0.00E+00
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	76	0.00E+00
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	74	0.00E+00
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	64	0.00E+00
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	64	0.00E+00
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	64	0.00E+00
Broccoli	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	53	1.00E-166
Papaya	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	63	7.00E-152
Cabbage	AT5G23010	MAM1	Methylthioalkylmalate synthase 1 chloroplastic	71	5.00E-151

GO ID	Ontology	GO Term	Description
GO:0009414	BP	response to water deprivation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
GO:0009507	CC	chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
GO:0009625	BP	response to insect	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.
GO:0010177	MF	2-(2'-methylthio)ethylmalate synthase activity	Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+.
GO:0019752	BP	carboxylic acid metabolic process	The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0019761	BP	glucosinolate biosynthetic process	The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
GO:0046912	MF	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.

Pubmed ID	Authors	Year	Title	Journal	Description
22336876	Redovnikovi_, I.R., Textor, S., Lisni_, B. & Gershenzon, J.	2012	Expression pattern of the glucosinolate side chain biosynthetic genes MAM1 and MAM3 of Arabidopsis thaliana in different organs and developmental stages	Plant Physiol Biochem
17369439	Textor, S., de Kraker, J.-W., Hause, B., Gershenzon, J. & Tokuhisa, J.G.	2007	MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis	Plant Physiology
N/A	Zang, Y.-X., Kim, D.-H., Park, B.-S. & Hong, S.-B.	2009	Metabolic engineering of indole glucosinolates in Chinese cabbage hairy roots expressing Arabidopsis CYP79B2, CYP79B3, and CYP83B1	Biotechnology and Bioprocess Engineering
N/A	Field, B., Cardon, G., Traka, M., Botterman, J., Vancanneyt, G. & Mithen, R.	2004	Glucosinolate and amino acid biosynthesis	Plant Physiology
21205930	de Kraker, J.W. & Gershenzon, J.	2011	From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis	Plant Cell
11706188	Kroymann, J., Textor, S., Tokuhisa, J.G., Falk, K.L., Bartram, S., Gershenzon, J. & Mitchell-Olds, T.	2001	A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway	Plant Physiology