SuCComBase

SCC Gene Description

Gene name	GGP3
AGI ID	AT4G30550
Gene length	249
Uniprot ID	Q9M0A5
Protein Name	Gamma-glutamyl peptidase 3
Synonym	N/A
EC number	EC 3.4.19.16
Entrez Gene	829178
Refseq mrna	NM_119201
Refseq protein	NP_194784
Function	Arabidopsis thaliana mutant impaired in the production of the γ-glutamyl peptidases GGP1 and GGP3 has altered glucosinolate levels and accumulates up to 10 related GSH conjugates. The double mutant is impaired in the production of camalexin and accumulates high amounts of the camalexin intermediate GS-IAN upon induction. In addition, the cellular and subcellular localization of GGP1 and GGP3 matches that of known glucosinolate and camalexin enzymes. GSH is the sulfur donor in the biosynthesis of glucosinolates and establish an in vivo function for the only known cytosolic plant γ-glutamyl peptidases, namely, the processing of GSH conjugates in the glucosinolate and camalexin pathways (Geu-Flores et al. 2011)
Group	Camalexin biosynthesis
Reference	Geu-Flores et al. (2011)

Organism	AGI ID	Gene Name	Protein Name	Identity	E-Value
Papaya	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	48.76	4.75E-84
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	68.313	2.53E-118
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	66.393	6.94E-117
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	67.078	1.05E-114
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	64.372	1.22E-113
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	87.097	1.51E-94
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	74.839	3.51E-79
Broccoli	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	75	5.01E-60
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	86.22	6.83E-160
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	80.328	9.18E-145
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	67.901	1.21E-117
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	67.901	8.60E-116
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	63.525	6.04E-108
Cabbage	AT4G30550	GGP3	Gamma-glutamyl peptidase 3	69.048	2.80E-101

GO ID	Ontology	GO Term	Description
GO:0003824	MF	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b
GO:0005737	CC	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005829	CC	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0006508	BP	proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0008233	MF	peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0019760	BP	glucosinolate metabolic process	The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim