SuCComBase

SCC Gene Description

Gene name	MYC4
AGI ID	AT4G17880
Gene length	589
Uniprot ID	O49687
Protein Name	Transcription factor MYC4
Synonym	AtbHLH4
EC number	N/A
Entrez Gene	827511
Refseq mrna	NM_117897.4
Refseq protein	NP_193522.1
Function	The myc2 myc3 myc4 (myc234) triple mutant was almost completely devoid of GSL and was extremely susceptible to the generalist herbivore Spodoptera littoralis. On the contrary the specialist Pieris brassicae was unaffected by the presence of GSL and preferred to feed on wild-type plants. In addition lack of GSL in myc234 drastically modified S. littoralis feeding behavior. Surprisingly the expression of MYB factors known to regulate GS biosynthesis genes was not altered in myc234; suggesting that MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes. Yeast two-hybrid and pull-down experiments indicated that MYC2/MYC3/MYC4 interact directly with GS-related MYBs. This specific MYC–MYB interaction plays a crucial role in the regulation of defense secondary metabolite production and underlines the importance of GSL in shaping plant interactions with adapted and nonadapted herbivores (Schweizer et al. 2013)
Group	GSL transcription factor
Reference	Schweizer et al. (2013)

Organism	AGI ID	Gene Name	Protein Name	Identity	E-Value	Description
Papaya	AT4G17880	MYC4	Transcription factor MYC4	71.318	1.05E-101
Papaya	AT4G17880	MYC4	Transcription factor MYC4	57.343	4.36E-73
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	73.55	0
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	63.107	0
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	50.88	2.86E-146
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	76.087	7.10E-105
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	58.996	1.25E-75
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	55.245	8.34E-72
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	55.869	1.73E-64
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	56.019	3.40E-59
Broccoli	AT4G17880	MYC4	Transcription factor MYC4	46.725	2.20E-55
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	71.01	0
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	64.527	0
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	62.932	0
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	50.72	2.07E-158
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	54.93	1.76E-63
Cabbage	AT4G17880	MYC4	Transcription factor MYC4	53.439	1.71E-54

GO ID	Ontology	GO Term	Description
GO:0003677	MF	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700	MF	transcription factor activity, sequence-specific DNA binding	A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter
GO:0005515	MF	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005634	CC	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some
GO:0006351	BP	transcription, DNA-templated	The cellular synthesis of RNA on a template of DNA.
GO:0006355	BP	regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006952	BP	defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
GO:0009718	BP	anthocyanin-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.
GO:0043425	MF	bHLH transcription factor binding	Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
GO:0045893	BP	positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:0046983	MF	protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

Pubmed ID	Authors	Year	Title	Journal	Description
23943862	Schweizer, F., Fern?ndez-calvo, P., Zander, M., Diez-diaz, M., Fonseca, S., Glauser, G., Lewsey, M.G., Ecker, J.R., Solano, R. & Reymond, P.	2013	Arabidopsis Basic Helix-Loop-Helix Transcription Factors MYC2,MYC3, andMYC4RegulateGlucosinolate Biosynthesis, Insect Performance, and Feeding Behavior	The Plant Cell