SuCComBase

SCC Gene Description

Gene name	CYP79B3
AGI ID	AT2G22330
Gene length	543
Uniprot ID	Q501D8
Protein Name	Tryptophan N-monooxygenase 2
Synonym	T26C19.1
EC number	EC 1.14.13.125
Entrez Gene	816765
Refseq mrna	NM_127798
Refseq protein	NP_179820
Function	Two Arabidopsis cytochrome P450s (CYP79B2 and CYP79B3) are able to convert Trp to indole-3-acetaldoxime (IAOx); a precursor to indole-3-acetic acid (IAA) and indole GSLs (Hull et al. 2000)
Group	GSL core structure synthesis / Camalexin biosynthesis
Reference	Hull et al. (2000); Mikkelsen et al. (2000); Mikkelsen et al. (2003); Zhao et al. (2015); Kettles et al. (2013); Su et al. (2011); Böttcher et al. (2009); Nafisi et al. (2007); Schuhegger et al. (2006); Glawischnig (2006); Schlaeppi et al. (2010); Glawisc

Organism	AGI ID	Gene Name	Protein Name	Identity	E-Value
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	93	0.00E+00
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	86	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	86	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	85	0.00E+00
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	85	0.00E+00
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	87	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	87	0.00E+00
Papaya	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	61	0.00E+00
Papaya	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	59	0.00E+00
Papaya	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	61	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	51	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	51	0.00E+00
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	45	1.00E-157
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	46	2.00E-157
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	46	4.00E-156
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	45	4.00E-153
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	45	4.00E-151
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	45	6.00E-148
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	48	1.00E-143
Broccoli	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	43	3.00E-136
Cabbage	AT2G22330	CYP79B3	Tryptophan N-monooxygenase 2	43	4.00E-135

GO ID	Ontology	GO Term	Description
GO:0002229	BP	defense response to oomycetes	Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism
GO:0004497	MF	monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
GO:0005506	MF	iron ion binding	Interacting selectively and non-covalently with iron (Fe) ions.
GO:0006569	BP	tryptophan catabolic process	The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0006952	BP	defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
GO:0009507	CC	chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
GO:0009611	BP	response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
GO:0009617	BP	response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
GO:0009625	BP	response to insect	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.
GO:0009682	BP	induced systemic resistance	A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling.
GO:0009684	BP	indoleacetic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.
GO:0010112	BP	regulation of systemic acquired resistance	Any process that modulates the frequency, rate or extent of systemic acquired resistance.
GO:0010120	BP	camalexin biosynthetic process	The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin.
GO:0016020	CC	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016021	CC	integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0016705	MF	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
GO:0016709	MF	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
GO:0019761	BP	glucosinolate biosynthetic process	The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
GO:0019825	MF	oxygen binding	Interacting selectively and non-covalently with oxygen (O2).
GO:0020037	MF	heme binding	Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0042742	BP	defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
GO:0052544	BP	defense response by callose deposition in cell wall	Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls.
GO:0055114	BP	oxidation-reduction process	A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

Pubmed ID	Authors	Year	Title	Journal
10681464	Hull, A.K., Vij, R. & Celenza, J.L.	2000	Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis	Proc Natl Acad Sci U S A
10922360	Mikkelsen, M.D., Hansen, C.H., Wittstock, U. & Halkier, B.A.	2000	Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid	J Biol Chem
25645692	Zhao, Y., Wang, J., Liu, Y., Miao, H., Cai, C., Shao, Z., Guo, R., Sun, B., Jia, C., Zhang, L., Gigolashvili, T. & Wang, Q.	2015	Classic myrosinase-dependent degradation of indole glucosinolate attenuates fumonisin B1-induced programmed cell death in Arabidopsis	Plant Journal
12529537	Mikkelsen, M.D., Petersen, B.L., Glawischnig, E., Jensen, A.B., Andreasson, E. & Halkier, B.A.	2003	Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways	Plant Physiology