SuCComBase

SCC Gene Description

Gene name	IGMT5
AGI ID	AT1G76790
Gene length	367
Uniprot ID	Q9SRD4
Protein Name	Indole glucosinolate O-methyltransferase 5
Synonym	F28O16.16
EC number	EC 2.1.1.-
Entrez Gene	844013
Refseq mrna	NM_106329
Refseq protein	NP_177805
Function	Biosynthesis of 1-methoxyindol-3-ylmethyl GSL (1MOI3M) from I3M involves the predicted instable intermediate 1-hydroxyindol-3-ylmethyl GSL (1OHI3M) and that IGMT5; a gene with moderate similarity to previously characterized IGMTs encodes the methyltransferase that is responsible for the conversion of 1OHI3M to 1MOI3M. Disruption of IGMT5 function increases resistance against the root-knot nematode Meloidogyne javanica and suggests a potential role for the 1-IG-modification pathway in Arabidopsis below-ground defense (Pfalz et al. 2016)
Group	GSL side chain modification
Reference	Pfalz et al. (2016)

Organism	AGI ID	Gene Name	Protein Name	Identity	E-Value
Papaya	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	44.142	9.85E-90
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	82.913	0
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	79.515	0
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	72.702	5.82E-180
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	72.778	8.89E-180
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	72.576	7.92E-179
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	71.389	2.55E-177
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	54.821	7.41E-122
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	53.514	2.44E-119
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	53.552	1.68E-118
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	53.825	5.02E-118
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	51.226	7.26E-111
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	50.833	1.45E-108
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	50.142	1.12E-96
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	46.721	1.06E-92
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	45.179	2.51E-90
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	44.875	2.02E-88
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	42.234	7.09E-82
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	61.435	2.46E-81
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	73.451	9.93E-59
Broccoli	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	51.456	2.72E-57
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	80.952	0
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	79.515	0
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	72.702	1.31E-180
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	72.778	1.64E-179
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	70.833	1.34E-175
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	83.936	5.33E-133
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	62.353	2.85E-131
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	55.738	6.19E-126
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	54.865	7.63E-121
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	54.821	9.48E-121
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	53.297	1.21E-117
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	52.926	2.47E-117
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	51.667	1.44E-110
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	77.626	2.62E-110
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	50.923	4.52E-110
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	50.133	4.49E-108
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	49.591	4.89E-98
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	49.856	9.79E-98
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	47.17	1.34E-93
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	73.039	5.87E-92
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	44.904	6.15E-90
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	57.463	2.04E-88
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	44.598	1.25E-87
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	42.703	2.66E-83
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	42.779	3.70E-83
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	40.51	5.41E-77
Cabbage	AT1G76790	IGMT5	Indole glucosinolate O-methyltransferase 5	74.336	5.85E-59

GO ID	Ontology	GO Term	Description
GO:0005829	CC	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0008171	MF	O-methyltransferase activity	Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
GO:0008757	MF	S-adenosylmethionine-dependent methyltransferase activity	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
GO:0009759	BP	indole glucosinolate biosynthetic process	The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.
GO:0032259	BP	methylation	The process in which a methyl group is covalently attached to a molecule.
GO:0046983	MF	protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

Pubmed ID	Authors	Year	Title	Journal	Description
27810943	Pfalz, M., Mukhaimar, M., Perreau, F., Kirk, J., Hansen, C.I.C., Olsen, C.E., Agerbirk, N. & Kroymann, J.	2016	Methyl transfer in glucosinolate biosynthesis mediated by indole glucosinolate O -methyltransferase 5	Plant Physiology