SuCComBase

Sulfur Containing Compound Database

SCC Gene Description

Gene name MYC2
AGI ID AT1G32640
Gene length 623
Uniprot ID Q39204
Protein Name Transcription factor MYC2
Synonym AtbHLH6
EC number N/A
Entrez Gene 840158
Refseq mrna NM_102998.4
Refseq protein NP_174541.1
Function The myc2 myc3 myc4 (myc234) triple mutant was almost completely devoid of GSL and was extremely susceptible to the generalist herbivore Spodoptera littoralis. On the contrary the specialist Pieris brassicae was unaffected by the presence of GSL and preferred to feed on wild-type plants. In addition lack of GSL in myc234 drastically modified S. littoralis feeding behavior. Surprisingly the expression of MYB factors known to regulate GS biosynthesis genes was not altered in myc234; suggesting that MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes. Yeast two-hybrid and pull-down experiments indicated that MYC2/MYC3/MYC4 interact directly with GS-related MYBs. This specific MYC–MYB interaction plays a crucial role in the regulation of defense secondary metabolite production and underlines the importance of GSL in shaping plant interactions with adapted and nonadapted herbivores (Schweizer et al. 2013)
Group GSL transcription factor
Reference Schweizer et al. (2013)
Organism AGI ID Gene Name Protein Name Identity E-Value Description

Papaya

AT1G32640

MYC2

Transcription factor MYC2

59.248

0

Papaya

AT1G32640

MYC3

Transcription factor MYC3

52.792

1.26E-51

Broccoli

AT1G32640

MYC4

Transcription factor MYC4

84.727

0

Broccoli

AT1G32640

MYC5

Transcription factor MYC5

79.859

0

Broccoli

AT1G32640

MYC6

Transcription factor MYC6

52.484

4.43E-171

Broccoli

AT1G32640

MYC7

Transcription factor MYC7

48.029

5.17E-136

Broccoli

AT1G32640

MYC8

Transcription factor MYC8

47.133

7.64E-134

Broccoli

AT1G32640

MYC9

Transcription factor MYC9

49.251

1.50E-119

Broccoli

AT1G32640

MYC10

Transcription factor MYC10

64.929

1.61E-78

Broccoli

AT1G32640

MYC11

Transcription factor MYC11

59.358

1.37E-65

Broccoli

AT1G32640

MYC12

Transcription factor MYC12

55.721

5.61E-57

Cabbage

AT1G32640

MYC13

Transcription factor MYC13

85.323

0

Cabbage

AT1G32640

MYC14

Transcription factor MYC14

54.237

1.28E-166

Cabbage

AT1G32640

MYC15

Transcription factor MYC15

47.648

1.36E-159

Cabbage

AT1G32640

MYC16

Transcription factor MYC16

50.261

5.00E-146

Cabbage

AT1G32640

MYC17

Transcription factor MYC17

46.042

2.56E-139

Cabbage

AT1G32640

MYC18

Transcription factor MYC18

46.865

7.57E-61

Cabbage

AT1G32640

MYC19

Transcription factor MYC19

53.953

9.83E-61

Cabbage

AT1G32640

MYC20

Transcription factor MYC20

48

4.89E-56

GO ID Ontology GO Term Description

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006568

BP

tryptophan metabolic process

The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.

GO:0009269

BP

response to desiccation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation

GO:0009611

BP

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

GO:0009737

BP

response to abscisic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.

GO:0009738

BP

abscisic acid-activated signaling pathway

A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0009759

BP

indole glucosinolate biosynthetic process

The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.

GO:0009867

BP

jasmonic acid mediated signaling pathway

A series of molecular signals mediated by jasmonic acid.

GO:0009963

BP

positive regulation of flavonoid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids.

GO:0010200

BP

response to chitin

A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus.

GO:0043565

MF

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

GO:0043619

BP

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0048364

BP

root development

The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwar

GO:0051090

BP

regulation of sequence-specific DNA binding transcription factor activity

Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

GO:2000068

BP

regulation of defense response to insect

Any process that modulates the frequency, rate or extent of defense response to insect.

Pubmed ID Authors Year Title Journal Description

23943862

Schweizer, F., Fern?ndez-calvo, P., Zander, M., Diez-diaz, M., Fonseca, S., Glauser, G., Lewsey, M.G., Ecker, J.R., Solano, R. & Reymond, P.

2013

Arabidopsis Basic Helix-Loop-Helix Transcription Factors MYC2,MYC3, andMYC4RegulateGlucosinolate Biosynthesis, Insect Performance, and Feeding Behavior

The Plant Cell