Arabidopsis Compound Description
| Knapsack ID | C00000125 |
| PubChem ID | 656506 |
| Compound name | 3-Indolylmethylglucosinolate (I3M) |
| Common Name | Glucobrassicin |
| Formula | C16H20N2O9S2 |
| SCC Type | Tryptophan derived glucosinolates; Indolylmethyl glucosinolates |
| SCC Function | The metabolic products of glucobrassicin, indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression in vitro and in vivo. With regards to suppressive activity, indole-3-carbinol has the ability to antagonize cell signaling pathways known to be dysregulated in prostate cancer (Watson et al. 2013). |
| Chemical Structure |  |
| Pubmed ID | Authors | Year | Title | Journal | Description |
|---|---|---|---|---|---|
|
Kliebenstein, D. J., Kroymann, J., Brown, P., Figuth, A., Pedersen, D., Gershenzon, J. & Mitchell-Olds, T. |
2001 |
Genetic Control of Natural Variation in Arabidopsis Glucosinolate Accumulation |
Plant Physiology |
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Brown, P.D., Tokuhisa, J.G., Reichelt, M. & Gershenzon, J. |
2003 |
Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana |
Phytochemistry |
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Watson, G. W., Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. |
2013 |
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. |
The AAPS journal |