Arabidopsis Compound Description
| Knapsack ID | C00001488 |
| PubChem ID | 23682211 |
| Compound name | 2-Propenyl glucosinolate |
| Common Name | Sinigrin |
| Formula | C10H17NO9S2 |
| SCC Type | Methionine-derived glucosinolates; Alkenyl glucosinolates |
| SCC Function | Sinigrin was found to significantly inhibit the proliferation of liver tumor cells; Sinigrin induced apoptosis of liver cancer cells through up-regulation of p53 and down-regulation of Bcl-2 family members and caspases. Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis, and highlight the potential of sinigrin as an anti-cancer agent for liver cancer (Jie et al 2014) |
| Chemical Structure |  |
| Pubmed ID | Authors | Year | Title | Journal | Description |
|---|---|---|---|---|---|
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Kliebenstein, D. J., Kroymann, J., Brown, P., Figuth, A., Pedersen, D., Gershenzon, J. & Mitchell-Olds, T. |
2001 |
Genetic Control of Natural Variation in Arabidopsis Glucosinolate Accumulation |
Plant Physiology |
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Reichelt, M., Brown, P.D., Schneider, B., Oldham, N.J., Stauber, E., Tokuhisa, J., Kliebenstein, D.J., Mitchell-Olds, T. & Gershenzon, J. |
2002 |
Benzoic acid glucosinolate esters and other glucosinolates from Arabidopsis thaliana |
Phytochemistry |
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Brown, P.D., Tokuhisa, J.G., Reichelt, M. & Gershenzon, J. |
2003 |
Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana |
Phytochemistry |
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Jie, M., Cheung, W. M., Yu, V., Zhou, Y., Tong, P. H., & Ho, J. W. |
2014 |
Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats. |
PloS one |