SuCComBase

GO:0003743

MF

translation initiation factor activity

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

GO:0005525

MF

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0005851

CC

eukaryotic translation initiation factor 2B complex

A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.

GO:0006413

BP

translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

GO:0016740

MF

transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the

GO:0044237

BP

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.