SuCComBase

Sulfur Containing Compound Database

SCC Gene Description

Gene name GSH2
AGI ID AT5G27380
Gene length 539
Uniprot ID P46416
Protein Name Glutathione synthetase chloroplastic
Synonym GSHB
EC number EC 6.3.2.3
Entrez Gene 832797
Refseq mrna NM_122620
Refseq protein NP_568495
Function Both gamma–glutamyl cysteine ligase (GSH1) and glutathione synthetase (GSH2); which catalyse its synthesis were significantly enriched in bundle sheath (BS) cells that can be related with sulfur and GSL metabolism (Aubry et al. 2014)
Group GSL core structure synthesis
Reference Bednarek et al. (2009); Aubry et al. (2014)
Organism AGI ID Gene Name Protein Name Identity E-Value Description

Cabbage

AT5G27380

GSH2

Glutathione synthetase chloroplastic

82

0.00E+00

Cabbage

AT5G27380

GSH2

Glutathione synthetase chloroplastic

84

0.00E+00

Broccoli

AT5G27380

GSH2

Glutathione synthetase chloroplastic

81

0.00E+00

Papaya

AT5G27380

GSH2

Glutathione synthetase chloroplastic

61

0.00E+00

GO ID Ontology GO Term Description

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

GO:0004363

MF

glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006520

BP

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.

GO:0006750

BP

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

GO:0009507

CC

chloroplast

A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

GO:0009753

BP

response to jasmonic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

Pubmed ID Authors Year Title Journal Description

24617819

Aubry, S., Smith-Unna, R.D., Boursnell, C.M., Kopriva, S. & Hibberd, J.M.

2014

Transcript residency on ribosomes reveals a key role for the Arabidopsis thaliana bundle sheath in sulfur and glucosinolate metabolism

Plant J

19095900

Bednarek, P., Pislewska-Bednarek, M., Svatos, A., Schneider, B., Doubsky, J., Mansurova, M., Humphry, M., Consonni, C., Panstruga, R., Sanchez-Vallet, A., Molina, A. & Schulze-Lefert, P.

2009

A Glucosinolate Metabolism Pathway in Living Plant Cells Mediates Broad-Spectrum Antifungal Defense

Science