SuCComBase

Sulfur Containing Compound Database

SCC Gene Description

Gene name GGP3
AGI ID AT4G30550
Gene length 249
Uniprot ID Q9M0A5
Protein Name Gamma-glutamyl peptidase 3
Synonym N/A
EC number EC 3.4.19.16
Entrez Gene 829178
Refseq mrna NM_119201
Refseq protein NP_194784
Function Arabidopsis thaliana mutant impaired in the production of the γ-glutamyl peptidases GGP1 and GGP3 has altered glucosinolate levels and accumulates up to 10 related GSH conjugates. The double mutant is impaired in the production of camalexin and accumulates high amounts of the camalexin intermediate GS-IAN upon induction. In addition, the cellular and subcellular localization of GGP1 and GGP3 matches that of known glucosinolate and camalexin enzymes. GSH is the sulfur donor in the biosynthesis of glucosinolates and establish an in vivo function for the only known cytosolic plant γ-glutamyl peptidases, namely, the processing of GSH conjugates in the glucosinolate and camalexin pathways (Geu-Flores et al. 2011)
Group Camalexin biosynthesis
Reference Geu-Flores et al. (2011)
Organism AGI ID Gene Name Protein Name Identity E-Value Description

Papaya

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

48.76

4.75E-84

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

68.313

2.53E-118

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

66.393

6.94E-117

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

67.078

1.05E-114

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

64.372

1.22E-113

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

87.097

1.51E-94

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

74.839

3.51E-79

Broccoli

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

75

5.01E-60

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

86.22

6.83E-160

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

80.328

9.18E-145

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

67.901

1.21E-117

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

67.901

8.60E-116

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

63.525

6.04E-108

Cabbage

AT4G30550

GGP3

Gamma-glutamyl peptidase 3

69.048

2.80E-101

GO ID Ontology GO Term Description

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific b

GO:0005737

CC

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005829

CC

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0006508

BP

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

GO:0019760

BP

glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in anim

Pubmed ID Authors Year Title Journal Description

21712415

Geu-Flores, F., Møldrup, M.E., Böttcher, C., Olsen, C.E., Scheel, D. and Halkier, B.A.

2011

Cytosolic γ-glutamyl peptidases process glutathione conjugates in the biosynthesis of glucosinolates and camalexin in Arabidopsis.

Plant Cell