SuCComBase

Sulfur Containing Compound Database

SCC Gene Description

Gene name MYC4
AGI ID AT4G17880
Gene length 589
Uniprot ID O49687
Protein Name Transcription factor MYC4
Synonym AtbHLH4
EC number N/A
Entrez Gene 827511
Refseq mrna NM_117897.4
Refseq protein NP_193522.1
Function The myc2 myc3 myc4 (myc234) triple mutant was almost completely devoid of GSL and was extremely susceptible to the generalist herbivore Spodoptera littoralis. On the contrary the specialist Pieris brassicae was unaffected by the presence of GSL and preferred to feed on wild-type plants. In addition lack of GSL in myc234 drastically modified S. littoralis feeding behavior. Surprisingly the expression of MYB factors known to regulate GS biosynthesis genes was not altered in myc234; suggesting that MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes. Yeast two-hybrid and pull-down experiments indicated that MYC2/MYC3/MYC4 interact directly with GS-related MYBs. This specific MYC–MYB interaction plays a crucial role in the regulation of defense secondary metabolite production and underlines the importance of GSL in shaping plant interactions with adapted and nonadapted herbivores (Schweizer et al. 2013)
Group GSL transcription factor
Reference Schweizer et al. (2013)
Organism AGI ID Gene Name Protein Name Identity E-Value Description

Papaya

AT4G17880

MYC4

Transcription factor MYC4

71.318

1.05E-101

Papaya

AT4G17880

MYC4

Transcription factor MYC4

57.343

4.36E-73

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

73.55

0

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

63.107

0

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

50.88

2.86E-146

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

76.087

7.10E-105

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

58.996

1.25E-75

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

55.245

8.34E-72

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

55.869

1.73E-64

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

56.019

3.40E-59

Broccoli

AT4G17880

MYC4

Transcription factor MYC4

46.725

2.20E-55

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

71.01

0

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

64.527

0

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

62.932

0

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

50.72

2.07E-158

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

54.93

1.76E-63

Cabbage

AT4G17880

MYC4

Transcription factor MYC4

53.439

1.71E-54

GO ID Ontology GO Term Description

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene in order to modulate transcription. Regulatory regions include promoter

GO:0005515

MF

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

GO:0005634

CC

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some

GO:0006351

BP

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

GO:0006355

BP

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0006952

BP

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

GO:0009718

BP

anthocyanin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

Pubmed ID Authors Year Title Journal Description

23943862

Schweizer, F., Fernández-calvo, P., Zander, M., Diez-diaz, M., Fonseca, S., Glauser, G., Lewsey, M.G., Ecker, J.R., Solano, R. & Reymond, P.

2013

Arabidopsis Basic Helix-Loop-Helix Transcription Factors MYC2,MYC3, andMYC4RegulateGlucosinolate Biosynthesis, Insect Performance, and Feeding Behavior

The Plant Cell